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Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

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Song,  Tao
University Bremen - MPI Joint Research Group for Marine Glycobiology, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Hehemann,  Jan Hendrik
University Bremen - MPI Joint Research Group for Marine Glycobiology, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Citation

Reisky, L., Buechsenschuetz, H. C., Engel, J., Song, T., Schweder, T., Hehemann, J. H., et al. (2018). Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases. Nature Chemical Biology, 14(4), 342-+. doi:10.1038/s41589-018-0005-8.


Cite as: http://hdl.handle.net/21.11116/0000-0003-B843-2
Abstract
Sugar O-methylation shields algal polysaccharides against microbial hydrolytic enzymes. Here, we describe cytochrome P450 monooxygenases from marine bacteria that, together with appropriate redox-partner proteins, catalyze the oxidative demethylation of 6-O-methyl-d-galactose, which is an abundant monosaccharide of the algal polysaccharides agarose and porphyran. This previously unknown biological function extends the group of carbohydrate-active enzymes to include the class of cytochrome P450 monooxygenases.