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Journal Article

Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe

MPS-Authors
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Mohamed,  Ahmed M. M.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Retzke,  Tom
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Das Chakraborty,  Sudeshna
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Fabian,  Benjamin
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;
Research Group Dr. S. Sachse, Olfactory Coding, MPI for Chemical Ecology, Max Planck Society;

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Hansson,  Bill S.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Knaden,  Markus
Research Group Dr. M. Knaden, Insect Behavior, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Sachse,  Silke
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

External Resource

http://dx.doi.org/10.1038/s41467-019-09069-1
(Publisher version)

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Fulltext (public)

SAC015.pdf
(Publisher version), 4MB

Supplementary Material (public)

SAC015s1.pdf
(Supplementary material), 5MB

Citation

Mohamed, A. M. M., Retzke, T., Das Chakraborty, S., Fabian, B., Hansson, B. S., Knaden, M., et al. (2019). Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe. Nature Communications, 10: 1201. doi:10.1038/s41467-019-09069-1.


Cite as: https://hdl.handle.net/21.11116/0000-0003-233A-5
Abstract
Evaluating odor blends in sensory processing is a crucial step for signal recognition and
execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have
characterized the neural and behavioral correlates of mixture perception in the olfactory
system of Drosophila. Mixtures of odors with opposing valences elicit strong inhibition in
certain attractant-responsive input channels. This inhibition correlates with reduced behavioral
attraction. We demonstrate that defined subsets of GABAergic interneurons provide
the neuronal substrate of this computation at pre- and postsynaptic loci via GABAB- and
GABAA receptors, respectively. Intriguingly, manipulation of single input channels by silencing
and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant-
and repellent-responsive circuits. This inhibitory interaction biases the behavioral
output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information.