Noninvasive cerebral blood flow monitoring by a dye bolus method: Separation of 
extra- and intracerebral absorption changes by frequency-domain spectroscopy

Kohl-Bareis, Matthias; Obrig, Hellmuth; Steinbrink, Jens; Malak, Jasmin; Uludag, Kamil; Villringer, Arno

doi:10.1117/12.434501

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Noninvasive cerebral blood flow monitoring by a dye bolus method: Separation of extra- and intracerebral absorption changes by frequency-domain spectroscopy

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Kohl-Bareis, M., Obrig, H., Steinbrink, J., Malak, J., Uludag, K., & Villringer, A. (2001). Noninvasive cerebral blood flow monitoring by a dye bolus method: Separation of extra- and intracerebral absorption changes by frequency-domain spectroscopy. In Proceedings of SPIE: Optical Tomography and Spectroscopy of Tissue IV (pp. 296-300). SPIE Digital Library. doi:10.1117/12.434501.

Cite as: https://hdl.handle.net/21.11116/0000-0003-4368-D

Abstract

Tracking a bolus of contrast agent traveling through the cerebral vasculature provides a measure of the blood supply and the blood flow velocity in the respective cerebral tissue. This principle has been the basis for the first approaches in functional MR imaging and is of great value when investigating stroke and other vascularly compromised patients. While the bolus measurement is a standard procedure in clinical MR imaging, optical bolus tracking has not yet become a reliable protocol. Here optical absorption changes induced by bolus signals of the dye indocyanine- green are studied by near infrared spectroscopy on volunteers. The aim is to assess the latency and shape of the absorption change.