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Journal Article

Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

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Deco,  Gustavo
Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
School of Psychological Sciences, Monash University, Melbourne, Australia;

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Citation

Stevner, A. B. A., Vidaurre, D., Cabral, J., Rapuano, K. M., Nielsen, S. F. V., Tagliazucchi, E., et al. (2019). Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nature Communications, 10(1): 1035. doi:10.1038/s41467-019-08934-3.


Cite as: https://hdl.handle.net/21.11116/0000-0003-2C74-A
Abstract
The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexity of whole-brain networks and state transitions during sleep. In order to obtain the most unbiased estimate of how whole-brain network states evolve through the human sleep cycle, we used a Markovian data-driven analysis of continuous neuroimaging data from 57 healthy participants falling asleep during simultaneous functional magnetic resonance imaging (fMRI) and EEG. This Hidden Markov Model (HMM) facilitated discovery of the dynamic choreography between different whole-brain networks across the wake-non-REM sleep cycle. Notably, our results reveal key trajectories to switch within and between EEG-based sleep stages, while highlighting the heterogeneities of stage N1 sleep and wakefulness before and after sleep.