Functional topography of early periventricular brain lesions in relation to 
cytoarchitectonic probabilistic maps

Staudt, M; Ticini, LF; Grodd, W; Kraegeloh-Mann, I; Karnath, H-O

doi:10.1016/j.bandl.2008.01.007

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Functional topography of early periventricular brain lesions in relation to cytoarchitectonic probabilistic maps

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https://www.sciencedirect.com/science/article/pii/S0093934X08000114
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Staudt, M., Ticini, L., Grodd, W., Kraegeloh-Mann, I., & Karnath, H.-O. (2008). Functional topography of early periventricular brain lesions in relation to cytoarchitectonic probabilistic maps. Brain and Language, 106(3), 177-183. doi:10.1016/j.bandl.2008.01.007.

Cite as: https://hdl.handle.net/21.11116/0000-0003-2D06-5

Abstract

Early periventricular brain lesions can not only cause cerebral palsy, but can also induce a reorganization of language. Here, we asked whether these different functional consequences can be attributed to topographically distinct portions of the periventricular white matter damage. Eight patients with pre- and perinatally acquired left-sided periventricular brain lesions underwent focal transcranial magnetic stimulation to assess the integrity of cortico-spinal hand motor projections, and functional MRI to determine the hemispheric organization of language production. MRI lesion-symptom mapping revealed that two distinct portions of the periventricular lesions were critically involved in the disruption of cortico-spinal hand motor projections on the one hand and in the induction of language reorganization into the contra-lesional right hemisphere on the other hand. Both regions are located in a position compatible with the course of cortico-spinal/cortico-nuclear projections of the primary motor cortex in the periventricular white matter, as determined by the stereotaxic probabilistic cytoarchitectonic atlas developed by the Jülich group.