English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes

MPS-Authors
/persons/resource/persons214962

Savić,  T
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83784

Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Ressource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Pujales-Paradela, R., Savić, T., Brandariz, I., Pérez-Lourido, P., Angelovski, G., Esteban-Gómez, D., et al. (2019). Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes. Chemical Communications, 55(28), 4115-4118. doi:10.1039/c9cc01204d.


Cite as: http://hdl.handle.net/21.11116/0000-0003-351C-3
Abstract
Reinforced cross-bridged Ni2+-cyclam complexes were functionalised with pendant arms containing both amide protons and CF3 groups that lead to a dual 1H/19F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni2+ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in 19F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.