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Journal Article

Integrin activation by talin, kindlin and mechanical forces

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Sun,  Zhiqi
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fässler,  Reinhard
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Sun, Z., Costell, M., & Fässler, R. (2019). Integrin activation by talin, kindlin and mechanical forces. Nature Cell Biology, 21(1), 25-31. doi:10.1038/s41556-018-0234-9.


Cite as: https://hdl.handle.net/21.11116/0000-0003-4284-D
Abstract
Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.