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Multicolor metabolic quantitative CEST (mmqCEST): high resolution imaging of brain metabolites

MPS-Authors
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Schuppert,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Khlebnikov, V., Bhogal, A., Schuppert, M., Zaiss, M., Lindig, T., Bender, B., et al. (2018). Multicolor metabolic quantitative CEST (mmqCEST): high resolution imaging of brain metabolites. In 7th International Workshop on Chemical Exchange Saturation Transfer (CEST 2018) (pp. 19).


Cite as: https://hdl.handle.net/21.11116/0000-0003-44F6-B
Abstract
The relatively low spatial resolution (ca. 250 mm3) of 1H-MRS hinders its application towards probing heterogeneous diseased tissue, e.g. tumor tissue. Therefore,
we present mmqCEST, a metabolic imaging technique based on the saturation transfer
from RF-tagged metabolites to the bulk water [1]. mmqCEST decodes a
frequency-dependent metabolite-weighted contrast in the Z-spectra into (multicolor)
quantitative metabolic maps with a high spatial resolution (ca. 3.4 mm3).