Fat corrected APT-CEST in the human breast

Zimmermann, F; Korzowski, A; Schuenke, P; Breitling, J; Zaiss, M; Paech, D; Ladd, ME; Bachert, P; Goerke, S

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Meeting Abstract

Fat corrected APT-CEST in the human breast

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Zaiss, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Zimmermann, F., Korzowski, A., Schuenke, P., Breitling, J., Zaiss, M., Paech, D., et al. (2018). Fat corrected APT-CEST in the human breast. In 7th International Workshop on Chemical Exchange Saturation Transfer (CEST 2018) (pp. 73).

Cite as: https://hdl.handle.net/21.11116/0000-0003-450A-5

Abstract

CEST in the mammary gland is affected by lipid signals1-5 not only causing strong pseudo rNOE artifacts4, but also leading to an incorrect normalization of the Z-spectrum in the spectral region of the amide proton transfer (APT) signal. Here, we propose to approximate the total fat signal by the residual magnetization at Δω = 0 ppm. This enables the correction of Z-spectra for fat signal induced artifacts without any
additional measurements and thus fat independent quantitative APT-CEST imaging.