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Journal Article

Orthogonally photocontrolled non-autonomous DNA walker.

MPS-Authors

Valero,  Julián
Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Famulok,  Michael
Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Citation

Skugor, M., Valero, J., Murayama, K., Centola, M., Asanuma, H., & Famulok, M. (2019). Orthogonally photocontrolled non-autonomous DNA walker. Angewandte Chemie International Edition in English, 58(21), 6948-6951. doi:10.1002/anie.201901272.


Cite as: http://hdl.handle.net/21.11116/0000-0003-50C1-8
Abstract
There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials and nano factories. We present an entirely light‐induced DNA walker based on orthogonal photo‐control. Implementing two azobenzene derivatives, S‐DM‐Azo and DM‐Azo, enabled precise coordination of strand displacement reactions that powered a biped walker and guided it along a defined track in a non‐autonomous way. This unprecedented type of molecular walker design offers high precision control over the movement in back‐and‐forth directions as desired, regulated solely by the sequence of the irradiation wavelengths. This concept may open new avenues for advancing non‐autonomous progressive molecular motors, ultimately facilitating their application on the nanoscale.