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Journal Article

Calcium influx through plasma-membrane nanoruptures drives Axon degeneration in a model of multiple sclerosis

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Griesbeck,  Oliver
Research Group: Tools for Bio-Imaging / Griesbeck, MPI of Neurobiology, Max Planck Society;

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1-s2.0-S0896627318311231-main.pdf
(Publisher version), 4MB

Supplementary Material (public)

1-s2.0-S0896627318311231-mmc2.mp4
(Supplementary material), 3MB

1-s2.0-S0896627318311231-mmc1.pdf
(Supplementary material), 7MB

Citation

Witte, M. E., Schumacher, A.-M., Mahler, C. F., Bewersdorf, J. P., Lehmitz, J., Scheiter, A., et al. (2019). Calcium influx through plasma-membrane nanoruptures drives Axon degeneration in a model of multiple sclerosis. Neuron, 101(4), 615-624.e5. doi:10.1016/j.neuron.2018.12.023.


Cite as: https://hdl.handle.net/21.11116/0000-0003-68A5-E
Abstract
Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.