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A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits

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Dirksen,  Philipp
Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Schulenburg,  Hinrich
Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Snoek, B. L., Volkers, R. J. M., Nijveen, H., Petersen, C., Dirksen, P., Sterken, M. G., et al. (2019). A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits. BMC Biology, 17(24), 1-17. doi:10.1186/s12915-019-0642-8.


Cite as: http://hdl.handle.net/21.11116/0000-0003-6FD5-1
Abstract
The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and the genetic regulators of trait variation can be mapped on the genome using quantitative trait locus (QTL) analysis of recombinant inbred lines (RILs) derived from genetically and phenotypically divergent parents. Most RILs have been derived from crossing two parents from globally distant locations. However, the genetic diversity between local C. elegans populations can be as diverse as between global populations and could thus provide means of identifying genetic variation associated with complex traits relevant on a broader scale.