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Book Chapter

Hepatocyte Targeting of Antiviral Drugs Coupled to Galactosyl-Terminating Glycoproteins


Wieland,  Theodor
Max Planck Institute for Medical Research, Max Planck Society;

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Fiume, L., Busi, C., Mattioli, A., Balboni, P. G., Barbanti-Brodano, G., & Wieland, T. (1982). Hepatocyte Targeting of Antiviral Drugs Coupled to Galactosyl-Terminating Glycoproteins. In G. Gregoriadis (Ed.), Targeting of Drugs (pp. 1-17). New York - N.Y., London: Plenum Press.

Cite as: http://hdl.handle.net/21.11116/0000-0003-6FD2-4
This chapter deals with the possibility of specifically introducing inhibitors of DNA synthesis into hepatocytes by conjugation to galactosyl-terminating glycoproteins which are selectively taken up by parenchymal liver cells (Morell et al., 1968; Ashwell and Morell, 1974; Gregoriadis, 1975). This line of research, which was developed as an approach to the treatment of chronic hepatitis B, started from the finding (Derenzini et al., 1973) that β-amanitin after coupling to albumin changed its original target Ed selectively penetrated into cells of the macrophage system which are very active in internalising albumin.