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Simultaneous FMRI/CBV and EEG During Spike-Wave Seizures in WAG/Rij Rats

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Schridde,  U
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mishra, A., Ellens, D., Schridde, U., Motelow, J., Purcaro, M., Hyder, F., et al. (2008). Simultaneous FMRI/CBV and EEG During Spike-Wave Seizures in WAG/Rij Rats. Poster presented at 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, Canada.


Cite as: http://hdl.handle.net/21.11116/0000-0003-930C-A
Abstract
In absence and other generalized seizure disorders, an abnormal electrical activity termed as spike-wave discharges (SWD) is observed by EEG. fMRI during SWD in humans and animal absence epilepsy models show both increases and decreases in BOLD signals. Here we show regional BOLD increases/decreases during SWD accompanied by CBV increases/decreases in nearly the same areas for anesthetized WAG/Rij rats. Further work will be needed to determine if regions of BOLD decreases during SWD represent vascular steal, a primary neuronal mechanism, or a defect in neurovascular coupling. These findings will be important for the interpretation of various fMRI signals in human absence epilepsy.