Fully active insulin by selective formation of the disulfide bridges between a 
synthetic A-chain and natural B-chain

Birr, Christian; Pipkorn, Rüdiger

doi:10.1002/anie.197905362

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Fully active insulin by selective formation of the disulfide bridges between a synthetic A-chain and natural B-chain

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Birr, Christian
Max Planck Institute for Medical Research, Max Planck Society;

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Pipkorn, Rüdiger
Max Planck Institute for Medical Research, Max Planck Society;

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https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.197905362
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https://doi.org/10.1002/anie.197905362
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引用

Birr, C., & Pipkorn, R. (1979). Fully active insulin by selective formation of the disulfide bridges between a synthetic A-chain and natural B-chain. Angewandte Chemie International Edition in English, 18(7), 536-538. doi:10.1002/anie.197905362.

引用: https://hdl.handle.net/21.11116/0000-0003-9367-3

要旨

Directed formation of the three disulfide bridges in insulin is a decisive synthetic step. Only 10% of insulin is formed on random recombination of A‐ and B‐ chains (1:1). An A‐chain synthesized with selectively removable sulfur protecting groups on a polymeric carrier was allowed to react with a natural B‐chain. The yield of fully active insulin increases to 25%.