Control of retrograde signalling by protein import and cytosolic folding stress

Wu, G.; Meyer, E. H.; Richter, Andreas S.; Schuster, M.; Ling, Qihua; Schöttler, M. A.; Walther, D.; Zoschke, R.; Grimm, Bernhard; Jarvis, R. Paul; Bock, R.

doi:10.1038/s41477-019-0415-y

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Control of retrograde signalling by protein import and cytosolic folding stress

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Wu, G.
Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Meyer, E. H.
Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Schuster, M.
Translational Regulation in Plants, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Schöttler, M. A.
Photosynthesis Research, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Walther, D.
BioinformaticsCIG, Infrastructure Groups and Service Units, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Zoschke, R.
Translational Regulation in Plants, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Bock, R.
Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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引用

Wu, G., Meyer, E. H., Richter, A. S., Schuster, M., Ling, Q., Schöttler, M. A., Walther, D., Zoschke, R., Grimm, B., Jarvis, R. P., & Bock, R. (2019). Control of retrograde signalling by protein import and cytosolic folding stress. Nature Plants, 5(5), 525-538. doi:10.1038/s41477-019-0415-y.

引用: https://hdl.handle.net/21.11116/0000-0003-95F3-2

要旨

Communication between organelles and the nucleus is essential for fitness and survival. Retrograde signals are cues emitted from the organelles to regulate nuclear gene expression. GENOMES UNCOUPLED1 (GUN1), a protein of unknown function, has emerged as a central integrator, participating in multiple retrograde signalling pathways that collectively regulate the nuclear transcriptome. Here, we show that GUN1 regulates chloroplast protein import through interaction with the import-related chaperone cpHSC70-1. We demonstrated that overaccumulation of unimported precursor proteins (preproteins) in the cytosol causes a GUN phenotype in the wild-type background and enhances the GUN phenotype of the gun1 mutant. Furthermore, we identified the cytosolic HSP90 chaperone complex, induced by overaccumulated preproteins, as a central regulator of photosynthetic gene expression that determines the expression of the GUN phenotype. Taken together, our results suggest a model in which protein import capacity, folding stress and the cytosolic HSP90 complex control retrograde communication.