Amide proton transfer (APT) MRI is a predictor of survival and progression in 
high-grade glioma patients

Paech, D; Dreher, C; Regnery, S; Meissner, J-E; Goerke, S; Windschuh, J; Deike-Hofmann, K; Bickelhaupt, S; Radbruch, A; Zaiss, M; Unterberg, A; Wick, W; Bendszus, M; Bachert, P; Ladd, M; Schlemmer, H-P

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Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients

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Zaiss, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/2919.html
(Zusammenfassung)

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Zitation

Paech, D., Dreher, C., Regnery, S., Meissner, J.-E., Goerke, S., Windschuh, J., et al. (2019). Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients. Poster presented at 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019), Montréal, QC, Canada.

Zitierlink: https://hdl.handle.net/21.11116/0000-0003-9D2C-C

Zusammenfassung

In this work we show that relaxation-compensated amide proton transfer (APT) imaging at 7.0 T is associated with overall survival and progression-free survival in newly-diagnosed, previously untreated glioma patients. The current study showed that glioma patients with increased APT values were more likely to progress sooner and live shorter, respectively. This effect may be caused by strong alterations of amino acid concentrations and global upregulation of protein expression in more aggressive brain tumors. Therefore, APT CEST imaging may help to enhance the prognostic value of non-invasive MRI tools at the time of initial diagnosis and during follow-up.