Reduced phallotoxin uptake by livers of young compared with adult rats

Walli , A. K.; Wieland , E.; Faulstich, Heinz; Wieland, Theodor

doi:10.1007/BF00505945

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Reduced phallotoxin uptake by livers of young compared with adult rats

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Faulstich, Heinz
Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society;

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Wieland, Theodor
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Walli, A. K., Wieland, E., Faulstich, H., & Wieland, T. (1979). Reduced phallotoxin uptake by livers of young compared with adult rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 307(3), 283-286. doi:10.1007/BF00505945.

Cite as: https://hdl.handle.net/21.11116/0000-0003-A3B5-8

Abstract

Using [3H]-demethylphalloin as a tracer the uptake of phallotoxins by the liver of young (6, 12, 16 days old) and adult rats was determined in relation to the dose of toxin administered. The maximum amount taken up by the livers of the young rats was only about 50% of that in adults. Nevertheless, with a dose as high as 55 mg/kg body weight the toxin concentration in the young liver reached more than 30 micrograms/g, being markedly higher than the minimum concentration (approximately 20 micrograms/g) required to cause irreversible damage of the liver in adult rats and death of the animals. This suggests that the tolerance of young rats to phallotoxins cannot solely be explained by the reduced uptake of the toxin.