English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

MPS-Authors
/persons/resource/persons200288

Opasic,  Luka
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons238284

Zhou,  Da
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56973

Traulsen,  Arne
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

External Resource

Link
(Publisher version)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Opasic_et_al-2019-BMC_Cancer.pdf
(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Opasic, L., Zhou, D., Werner, B., Dingli, D., & Traulsen, A. (2019). How many samples are needed to infer truly clonal mutations from heterogenous tumours? BMC Cancer, 19: 403. doi:10.1186/s12885-019-5597-1.


Cite as: https://hdl.handle.net/21.11116/0000-0003-A456-3
Abstract
Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. However, the identification of truly clonal alterations is impaired by the tremendous intra-tumour genetic heterogeneity and unavoidable sampling biases.