How many samples are needed to infer truly clonal mutations from heterogenous 
tumours?

Opasic, Luka; Zhou, Da; Werner, Benjamin; Dingli, David; Traulsen, Arne

doi:10.1186/s12885-019-5597-1

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How many samples are needed to infer truly clonal mutations from heterogenous tumours?

MPS-Authors

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Opasic, Luka
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Zhou, Da
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Traulsen, Arne
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Opasic_et_al-2019-BMC_Cancer.pdf
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引用

Opasic, L., Zhou, D., Werner, B., Dingli, D., & Traulsen, A. (2019). How many samples are needed to infer truly clonal mutations from heterogenous tumours? BMC Cancer, 19:. doi:10.1186/s12885-019-5597-1.

引用: https://hdl.handle.net/21.11116/0000-0003-A456-3

要旨

Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. However, the identification of truly clonal alterations is impaired by the tremendous intra-tumour genetic heterogeneity and unavoidable sampling biases.