Magnetization Transfer Ratio Imaging in Multiple Sclerosis: a Comparison of 3D 
Balanced Steady-State Free Precession and 2D Gradient Echo Sequences in 
Clinical Studies

Hirsch, JG; Bieri, O; Scheffler, K; Thoeni, A; Radue, E-W; Kappos, L; Gass, A

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Meeting Abstract

Magnetization Transfer Ratio Imaging in Multiple Sclerosis: a Comparison of 3D Balanced Steady-State Free Precession and 2D Gradient Echo Sequences in Clinical Studies

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https://www.ismrm.org/08/
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Zitation

Hirsch, J., Bieri, O., Scheffler, K., Thoeni, A., Radue, E.-W., Kappos, L., et al. (2008). Magnetization Transfer Ratio Imaging in Multiple Sclerosis: a Comparison of 3D Balanced Steady-State Free Precession and 2D Gradient Echo Sequences in Clinical Studies. In 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008) (pp. 98).

Zitierlink: https://hdl.handle.net/21.11116/0000-0003-AA07-6

Zusammenfassung

There is great need for techniques, that quantitatively assess subtle tissue changes beyond the gross pathology in multiple sclerosis. We evaluated a new 3DbSSFP MTR protocol yielding maximal sensitivity to MT in human brain. We compared this 3D-bSSFP with the commonly used 2D-GRE approach in a clinical setup, and evaluated the advantages of bSSFP in a quantitative study on 20 MS patients. Protocols were adjusted to similar acquisition times while
using optimized sequence settings for both approaches. Higher, and esp. isotropic resolution, whole brain coverage, and stronger grey-white matter MTR contrast turned out to be the important advantages of 3D-bSSFP.