Multi-echo segmented diffusion-weighted MRI for ex-vivo whole-brain 
measurements with 300mT/m gradients

Eichner, Cornelius; Mildner, Toralf; Paquette, Michael; Schlumm, Torsten; Crockford, Catherine; Wittig, Roman M.; Kirilina, Evgeniya; Jäger, Carsten; Möller, Harald E.; Weiskopf, Nikolaus; Friederici, Angela D.; Anwander, Alfred

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Meeting Abstract

Multi-echo segmented diffusion-weighted MRI for ex-vivo whole-brain measurements with 300mT/m gradients

MPS-Authors

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Eichner, Cornelius
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mildner, Toralf
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons220619

Paquette, Michael
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schlumm, Torsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Crockford, Catherine
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Wittig, Roman M.
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Kirilina, Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons213123

Jäger, Carsten
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19864

Möller, Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons147461

Weiskopf, Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19643

Friederici, Angela D.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19530

Anwander, Alfred
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Eichner, C., Mildner, T., Paquette, M., Schlumm, T., Crockford, C., Wittig, R. M., et al. (2019). Multi-echo segmented diffusion-weighted MRI for ex-vivo whole-brain measurements with 300mT/m gradients. In Proceedings of the 27th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM).

Cite as: https://hdl.handle.net/21.11116/0000-0003-ABEE-1

Abstract

We provide a novel method to increase SNR of segmented diffusion-weighted EPI acquisitions. Multiple gradient echoes were acquired after each diffusion-preparation and combined in an SNR-optimized way using weightings from quantitative T2* maps. The combination of diffusion-weighted echoes yielded an SNR-gain of 58% compared to single-echo dMRI data with an increase in the segmented readout duration by only 23.1 ms. The multi-echo diffusion MRI acquisition and combination were employed to acquire high-quality ex-vivo diffusion-weighted MRI data from a wild chimpanzee brain.