Compartmentalised RNA catalysis in membrane-free coacervate protocells.

Drobot, Björn; Iglesias-Artola, Juan M; Vay, Kristian Le; Mayr, Viktoria; Kar, Mrityunjoy; Kreysing, Moritz; Mutschler, Hannes; Tang, T-Y Dora

doi:10.1038/s41467-018-06072-w

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Compartmentalised RNA catalysis in membrane-free coacervate protocells.

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Drobot, Björn
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Mayr, Viktoria
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Kar, Mrityunjoy
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Kreysing, Moritz
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Tang, T-Y Dora
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Drobot, B., Iglesias-Artola, J. M., Vay, K. L., Mayr, V., Kar, M., Kreysing, M., et al. (2018). Compartmentalised RNA catalysis in membrane-free coacervate protocells. Nature communications, 9(1): 3643. doi:10.1038/s41467-018-06072-w.

Cite as: https://hdl.handle.net/21.11116/0000-0003-F5DB-2

Abstract

Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have been important for driving primitive reactions as part of the RNA world hypothesis. However, to date, RNA catalysis has not been reconciled with coacervation. Here we demonstrate that RNA catalysis is viable within coacervate microdroplets and further show that these membrane-free droplets can selectively retain longer length RNAs while permitting transfer of lower molecular weight oligonucleotides.