The genome of Schmidtea mediterranea and the evolution of core cellular 
mechanisms.

Grohme, Markus; Schloissnig, Siegfried; Rozanski, Andrei; Pippel, Martin; Young, George Robert; Winkler, Sylke; Brandl, Holger; Henry, Ian; Dahl, Andreas; Powell, Sean; Hiller, Michael; Myers, Eugene; Rink, Jochen

doi:10.1038/nature25473

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The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.

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Grohme, Markus
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Rozanski, Andrei
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219793

Winkler, Sylke
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219032

Brandl, Holger
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219236

Henry, Ian
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons184581

Hiller, Michael
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219475

Myers, Eugene
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219585

Rink, Jochen
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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https://publications.mpi-cbg.de/Grohme_2018_7065.pdf
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Citation

Grohme, M., Schloissnig, S., Rozanski, A., Pippel, M., Young, G. R., Winkler, S., et al. (2018). The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms. Nature, 554(7690), 56-61. doi:10.1038/nature25473.

Cite as: https://hdl.handle.net/21.11116/0000-0003-F5F3-6

Abstract

The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.