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Journal Article

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.

MPS-Authors
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Delpierre,  Julien
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Meyer,  Kirstin
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219807

Zerial,  Marino
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Tanaka, H., Imasato, M., Yamazaki, Y., Matsumoto, K., Kunimoto, K., Delpierre, J., et al. (2018). Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. Journal of hepatology, 69(6), 1308-1316. doi:10.1016/j.jhep.2018.08.025.


Cite as: https://hdl.handle.net/21.11116/0000-0003-F69A-A
Abstract
Most cholesterol gallstones have a core consisting of inorganic and/or organic calcium salts, although the mechanisms of core formation are poorly understood. We examined whether the paracellular permeability of ions at hepatic tight junctions is involved in the core formation of cholesterol gallstones, with particular interest in the role of phosphate ion, a common food additive and preservative.