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Journal Article

Layer-by-Layer Assembly of Heparin and Peptide-Polyethylene Glycol Conjugates to Form Hybrid Nanothin Films of Biomatrices.

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Friedrichs,  Jens
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Bickle,  Marc
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Thomas, A. K., Wieduwild, R., Zimmermann, R., Lin, W., Friedrichs, J., Bickle, M., et al. (2018). Layer-by-Layer Assembly of Heparin and Peptide-Polyethylene Glycol Conjugates to Form Hybrid Nanothin Films of Biomatrices. ACS applied materials & interfaces, 10(17), 14264-14270. doi:10.1021/acsami.8b02014.


Cite as: https://hdl.handle.net/21.11116/0000-0003-F6A2-0
Abstract
We investigated the utility of a heparin/peptide-polyethylene glycol conjugate system to build layer-by-layer (LbL) structures, to assemble tailored multilayer-biomatrices for cell culture. The LbL assembly balances the advantages of polyelectrolyte systems and protein-based systems. Human umbilical vein endothelial cells showed distinct responses to the film thickness and structure; the presence, density, and spatial arrangement of a cell adhesion ligand within the nanothin film; and the pretreatment of the film with morphogens. The LbL technique presents a versatile tool for modifying cell culture substrates with defined and diverse biochemical and structural features, for investigating cell-material interactions.