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Journal Article

miRNA functions in stem cells and their niches: Lessons from the Drosophila ovary.

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Shcherbata,  H. R.
Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society;

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Citation

Shcherbata, H. R. (2019). miRNA functions in stem cells and their niches: Lessons from the Drosophila ovary. Current Opinion in Insect Science, 31, 29-36. doi:10.1016/j.cois.2018.07.006.


Cite as: http://hdl.handle.net/21.11116/0000-0003-ADDB-4
Abstract
From the very beginning of the miRNA era, Drosophila has served as an excellent model for explanation of miRNA biogenesis. Now Drosophila continues to be used in numerous studies aiming to decipher biological roles of individual miRNAs in a living organism. MiRNAs have emerged as an important regulatory class that adjusts gene expression in response to stress; therefore, it is particularly important to elucidate miRNA-based regulatory networks that appear in response to fluctuations in intrinsic and extrinsic environments. This review explores the major advances in understanding condition-dependent roles of miRNAs in adult stem cell biology using the Drosophila ovarian germline stem cell niche community as a model system.