Control of Eukaryotic DNA Replication Initiation-Mechanisms to Ensure Smooth 
Transitions

Reußwig, Karl-Uwe; Pfander, Boris

doi:10.3390/genes10020099

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Control of Eukaryotic DNA Replication Initiation-Mechanisms to Ensure Smooth Transitions

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Reußwig, Karl-Uwe
Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society;

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Pfander, Boris
Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society;

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Reußwig, K.-U., & Pfander, B. (2019). Control of Eukaryotic DNA Replication Initiation-Mechanisms to Ensure Smooth Transitions. Genes, 10(2): 99. doi:10.3390/genes10020099.

Cite as: https://hdl.handle.net/21.11116/0000-0003-DE07-C

Abstract

DNA replication differs from most other processes in biology in that any error will irreversibly change the nature of the cellular progeny. DNA replication initiation, therefore, is exquisitely controlled. Deregulation of this control can result in over-replication characterized by repeated initiation events at the same replication origin. Over-replication induces DNA damage and causes genomic instability. The principal mechanism counteracting over-replication in eukaryotes is a division of replication initiation into two steps-licensing and firing-which are temporally separated and occur at distinct cell cycle phases. Here, we review this temporal replication control with a specific focus on mechanisms ensuring the faultless transition between licensing and firing phases.