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Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Clayton, S., Barquera, R., Uribe-Duarte, M. G., Vázquez, I. G., Zúñiga, J., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa. Human Immunology, 2019.06.006. doi:10.1016/j.humimm.2019.06.006.


Cite as: http://hdl.handle.net/21.11116/0000-0003-C3D9-C
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47) and Native American (37.61 ± 2.85), while the African genetic component was estimated as virtually absent (0.00 ± 1.86).