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Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

González-Medina, L., Barquera, R., Delgado-Aguirre, H., Clayton, S., Adalid-Sáinz, C., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango. Human Immunology, 2019.06.005. doi:10.1016/j.humimm.2019.06.005.


Cite as: http://hdl.handle.net/21.11116/0000-0003-C3E4-F
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 479 Mexicans from the state of Durango living in Durango city (N = 153) and rural communities (N = 326), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Durango include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Durango are European (54.34 ± 1.68) and Native American (45.66 ± 2.24), while African genetic component was virtually absent (0.00 ± 2.03). However, African haplotypes could be estimated at a proportion of 9.13.