English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit

MPS-Authors
/persons/resource/persons214002

Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202721

Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Goné-Vázquez, I., Barquera, R., Arellano-Prado, F. P., Hernández-Zaragoza, D. I., Escobedo-Ruíz, A., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit. Human Immunology, 2019.06.008. doi:10.1016/j.humimm.2019.06.008.


Cite as: https://hdl.handle.net/21.11116/0000-0003-C3F0-1
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 161 Mexicans from the state of Nayarit living in Tepic (N = 97) and rural communities (N = 64), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Nayarit include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nayarit are Native American (50.79 ± 5.03 by ML; 42.24 of Native American haplotypes) and European (37.04 ± 6.21 by ML; 35.72 of European haplotypes), while African genetic component is less apparent but relatively high (12.17 ± 2.50 by ML; 13.36 of African haplotypes).