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Journal Article

Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Escobedo-Ruíz, A., Barquera, R., González-Martín, A., Millán, J.-M.-A.-S., Uribe-Duarte, M. G., Hernández-Zaragoza, D. I., et al. (2020). Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California. Human Immunology, 81(9): 2019.06.007, pp. 475-477. doi:10.1016/j.humimm.2019.06.007.


Cite as: https://hdl.handle.net/21.11116/0000-0003-C7C6-D
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84 by ML; 42.03 of European haplotypes) and Native American (43.72 ± 2.36 by ML; 40.24 of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98 by ML; 9.36 of African haplotypes).