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Book Chapter

Imaging Signal Transduction in Dendrites Using Genetically Encoded Biosensors


Yasuda,  Ryohei
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Murakoshi, H., & Yasuda, R. (2016). Imaging Signal Transduction in Dendrites Using Genetically Encoded Biosensors. In Dendrites (pp. 139-154). Tokyo: Springer. Retrieved from https://link.springer.com/chapter/10.1007/978-4-431-56050-0_7.

Cite as: https://hdl.handle.net/21.11116/0000-0003-D4EE-2
Activity-dependent synaptic plasticity is the basis of circuit plasticity and, ultimately, behavioral plasticity, learning, and memory. Intracellular signal transduction, mediated by hundreds of species of signaling proteins in dendrites, plays an important role in linking postsynaptic neuronal activity with synaptic plasticity. Recent advances in the development of fluorescent protein-based biosensors and optical techniques have enabled us to image signal transduction with the resolution of single synapses, revealing the mechanism by which spatiotemporal dynamics of biochemical signaling are regulated in dendrites and synapses. In this chapter, we will review genetically encoded fluorescent protein-based sensors, Förster resonance energy transfer (FRET) imaging, and recent discoveries based on these techniques.