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Journal Article

The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism

MPS-Authors

Hyun,  Jung Ho
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Kwon,  Hyung-Bae
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Citation

Beas, B. S., Wright, B. J., Skirzewski, M., Leng, Y., Hyun, J. H., Koita, O., et al. (2018). The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nature Neuroscience, 963-973. Retrieved from https://www.nature.com/articles/s41593-018-0167-4.


Cite as: https://hdl.handle.net/21.11116/0000-0003-D518-2
Abstract
Beas et al. show that stress exposure drives disinhibition of PVT projection neurons. This process involves an LC-mediated rise in extracellular DA in the midline thalamus, requires D2 receptors on PVT neurons, and increases stress sensitivity.