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Journal Article

SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits

MPS-Authors

Gaffield,  Michael A.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Christie,  Jason M.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Citation

Michaelson, S. D., Ozkan, E. D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., et al. (2018). SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits. Nature Neuroscience, 1-13. Retrieved from https://www.nature.com/articles/s41593-018-0268-0.


Cite as: https://hdl.handle.net/21.11116/0000-0003-D514-6
Abstract
Michaelson et al. report that human SYNGAP1 variation alters touch-related sensory processing. Studies in Syngap1 mice revealed circuit-specific impairments in the somatosensory cortex that underlie reduced cortical activation in response to touch.