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Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

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Barquera Lozano,  Rodrigo José
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Barquera Lozano, R. J., Hernández-Zaragoza, D. I., Arellano-Prado, F. P., Goné-Vázquez, I., Clayton, S., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima. Human Immunology. doi:10.1016/j.humimm.2019.06.004.


Cite as: http://hdl.handle.net/21.11116/0000-0003-D653-E
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 ± 3.88 by ML; 48.10 of Native American haplotypes) and European (37.52 ± 8.94 by ML; 26.66 of European haplotypes), and a relatively high African genetic component (9.74 ± 8.40 by ML; 11.91 of African haplotypes). © 2019 American Society for Histocompatibility and Immunogenetics