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Preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide

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Seeberger,  Peter H.
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Abstract
The disclosure discloses a preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide , and belongs to the field of carbohydrate chemistry . The structure of the outer core octasaccharide of Helicobacter pylori is ( a - D - Glc - ( 1 - 3 ) - a - D - Glc - ( 1 - 4 ) - B - D - Gal - ( 1 - 7 ) - D a - D - Hep?a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 2 ) - D a - D - Hep ] - Linker . The structure consists of three monosac charides : glucose , galactose and heptose . It contains five a - glycosidic bonds of glucose , one ß - glycosidic bond of galactose and two a - glycosidic bonds of heptose . The dis closure prepares the octasaccharide by the synergistic action of remote neighboring group participation effect , solvent effect , temperature effect , additives and leaving groups . The reducing end of the octasaccharide may also be linked with a linker for future attachment to the protein to form a glycoconjugate for immunological studies .