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Patent

Preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide

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Seeberger,  Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Seeberger, P. H.(2019). Preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide. United States: US20190177441A1. Retrieved from https://patents.google.com/patent/US20190177441A1/en.


Cite as: https://hdl.handle.net/21.11116/0000-0003-E6AE-6
Abstract
The disclosure discloses a preparation method of outer core
octasaccharide of Helicobacter pylori lipopolysaccharide ,
and belongs to the field of carbohydrate chemistry . The
structure of the outer core octasaccharide of Helicobacter
pylori is ( a - D - Glc - ( 1 - 3 ) - a - D - Glc - ( 1 - 4 ) - B - D - Gal - ( 1 - 7 ) - D
a - D - Hep?a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 2 ) - D
a - D - Hep ] - Linker . The structure consists of three monosac
charides : glucose , galactose and heptose . It contains five
a - glycosidic bonds of glucose , one ß - glycosidic bond of
galactose and two a - glycosidic bonds of heptose . The dis
closure prepares the octasaccharide by the synergistic action
of remote neighboring group participation effect , solvent
effect , temperature effect , additives and leaving groups . The
reducing end of the octasaccharide may also be linked with
a linker for future attachment to the protein to form a
glycoconjugate for immunological studies .