Protein-level assembly increases protein sequence recovery from metagenomic 
samples manyfold.

Steinegger, M.; Mirdita, M.; Söding, J.

doi:10.1038/s41592-019-0437-4

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Protein-level assembly increases protein sequence recovery from metagenomic samples manyfold.

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Steinegger, M.
Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Mirdita, M.
Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Söding, J.
Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society;

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引用

Steinegger, M., Mirdita, M., & Söding, J. (2019). Protein-level assembly increases protein sequence recovery from metagenomic samples manyfold. Nature Methods, 16, 603-606. doi:10.1038/s41592-019-0437-4.

引用: https://hdl.handle.net/21.11116/0000-0003-E0DD-7

要旨

The open-source de novo protein-level assembler, Plass ( https://plass.mmseqs.com ), assembles six-frame-translated sequencing reads into protein sequences. It recovers 2-10 times more protein sequences from complex metagenomes and can assemble huge datasets. We assembled two redundancy-filtered reference protein catalogs, 2 billion sequences from 640 soil samples (soil reference protein catalog) and 292 million sequences from 775 marine eukaryotic metatranscriptomes (marine eukaryotic reference catalog), the largest free collections of protein sequences.