Metabolome signature of autism in the human prefrontal cortex

Kurochkin, Ilia; Khrameeva, Ekaterina; Tkachev, Anna; Stepanova, Vita; Vanyushkina, Anna; Stekolshchikova, Elena; Li, Qian; Zubkov, Dmitry; Shichkova, Polina; Halene, Tobias; Willmitzer, L.; Giavalisco, Patrick; Akbarian, Schahram; Khaitovich, Philipp

doi:10.1038/s42003-019-0485-4

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Metabolome signature of autism in the human prefrontal cortex

MPS-Authors

/persons/resource/persons97481

Willmitzer, L.
Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Kurochkin, I., Khrameeva, E., Tkachev, A., Stepanova, V., Vanyushkina, A., Stekolshchikova, E., Li, Q., Zubkov, D., Shichkova, P., Halene, T., Willmitzer, L., Giavalisco, P., Akbarian, S., & Khaitovich, P. (2019). Metabolome signature of autism in the human prefrontal cortex. Communications Biology, 2(1):. doi:10.1038/s42003-019-0485-4.

引用: https://hdl.handle.net/21.11116/0000-0003-E703-5

要旨

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD.