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Journal Article

Trends in trapped ion mobility - Mass spectrometry instrumentation


Mann,  Matthias
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Ridgeway, M. E., Bleiholder, C., Mann, M., & Park, M. A. (2019). Trends in trapped ion mobility - Mass spectrometry instrumentation. TrAC-Trends in Analytical Chemistry, 116, 324-331. doi:10.1016/j.trac.2019.03.030.

Cite as: https://hdl.handle.net/21.11116/0000-0003-E969-1
Trapped Ion Mobility Spectrometry (TIMS) is a recently developed form of ion mobility spectrometry (IMS) which is flexible in its operation and readily hybridized with mass spectrometry (MS). Prototype TIMS-MS instruments are applicable to a wide range of analytical problems including separation of isobars and isomers, the study of analyte conformation and unfolding, general separation of complex mixtures, and omics. Hybridization of TIMS with high performance mass analyzers such as ion cyclotron resonance (ICR) allows for the more effective analysis of highly complex samples. Adding trapping ahead of TIMS has enabled technologies such as Parallel Accumulation Serial Fragmentation (PASEF) for improved shotgun proteomics. Finally, tandem TIMS (tTIMS) adds flexibility, especially in top down proteomics. Here we highlight recent advances in TIMS-MS and their analytical applications. (C) 2019 Published by Elsevier B.V.