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Nickel‐Catalyzed Cascade Annulation for the Rapid Synthesis of Carbocyclic Nitriles

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Fang,  Xianjie
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Yu,  Peng
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Willems,  Suzanne
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Morandi,  Bill
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fang, X., Yu, P., Willems, S., & Morandi, B. (2019). Nickel‐Catalyzed Cascade Annulation for the Rapid Synthesis of Carbocyclic Nitriles. Helvetica Chimica Acta, 102(5): e1900059. doi:10.1002/hlca.201900059.


Cite as: https://hdl.handle.net/21.11116/0000-0004-3FA3-E
Abstract
We report a Ni‐catalyzed cascade annulation reaction that proceeds through two sequential carbometallation steps followed by C−CN reductive elimination. This reaction transforms two simple starting materials into complex, carbocyclic nitriles.