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Journal Article

Molecular Engineering of the TGF-β Signaling Pathway


Zi,  Zhike
Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zi, Z. (2019). Molecular Engineering of the TGF-β Signaling Pathway. Journal of Molecular Biology (London), 431(15), 2644-2654. doi:10.1016/j.jmb.2019.05.022.

Cite as: http://hdl.handle.net/21.11116/0000-0003-F2A7-F
Transforming growth factor beta (TGF-β) is an important growth factor that plays essential roles in regulating tissue development and homeostasis. Dysfunction of TGF-β signaling is a hallmark of many human diseases. Therefore, targeting TGF-β signaling presents broad therapeutic potential. Since the discovery of the TGF-β ligand, a collection of engineered signaling proteins have been developed to probe and manipulate TGF-β signaling responses. In this review, we highlight recent progress in the engineering of TGF-β signaling for different applications and discuss how molecular engineering approaches can advance our understanding of this important pathway. In addition, we provide a future outlook on the opportunities and challenges in the engineering of the TGF-β signaling pathway from a quantitative perspective.