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Association of estradiol and visceral fat with structural brain networks and memory performance in adults

MPS-Authors
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Zsido,  Rachel
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Heinrich,  Matthias
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Beyer,  Frauke
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Kharabian,  Shahrzad
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mueller,  Karsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Scharrer,  Ulrike
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Schroeter,  Matthias L.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;

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Witte,  A. Veronica
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Sacher,  Julia
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Zsido_2019.pdf
(Publisher version), 3MB

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Citation

Zsido, R., Heinrich, M., Slavich, G. M., Beyer, F., Kharabian, S., Kratzsch, J., et al. (2019). Association of estradiol and visceral fat with structural brain networks and memory performance in adults. JAMA Network Open, 2(6): e196126. doi:10.1001/jamanetworkopen.2019.6126.


Cite as: http://hdl.handle.net/21.11116/0000-0003-F9A7-8
Abstract
Importance Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss. Objectives To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure. Design, Setting, and Participants Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT as the moderator variable between age and brain network structure and estradiol as the moderator variable between VAT and brain network structure. The study was conducted from August 1, 2011, to November 23, 2014. Analyses were conducted from August 2017 to September 2018