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Paleomicrobiology: Diagnosis and Evolution of Ancient Pathogens

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Bos,  Kirsten I.
CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society;
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Kühnert,  Denise
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons179620

Herbig,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Esquivel Gomez,  Luis Roger
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

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Andrades Valtueña,  Aida
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Barquera Lozano,  Rodrigo José
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Giffin,  Karen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Lankapalli,  Aditya Kumar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Nelson,  Elizabeth A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Sabin,  Susanna
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Spyrou,  Maria A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Krause,  Johannes
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Bos, K. I., Kühnert, D., Herbig, A., Esquivel Gomez, L. R., Andrades Valtueña, A., Barquera Lozano, R. J., et al. (2019). Paleomicrobiology: Diagnosis and Evolution of Ancient Pathogens. Annual Review of Microbiology, 73(1), 29.1-29.28. doi:10.1146/annurev-micro-090817-062436.


Cite as: http://hdl.handle.net/21.11116/0000-0004-41AA-3
Abstract
The last century has witnessed progress in the study of ancient infectious disease from purely medical descriptions of past ailments to dynamic interpretations of past population health that draw upon multiple perspectives. The recent adoption of high-throughput DNA sequencing has led to an expanded understanding of pathogen presence, evolution, and ecology across the globe. This genomic revolution has led to the identification of disease-causing microbes in both expected and unexpected contexts, while also providing for the genomic characterization of ancient pathogens previously believed to be unattainable by available methods. In this review we explore the development of DNA-based ancient pathogen research, the specialized methods and tools that have emerged to authenticate and explore infectious disease of the past, and the unique challenges that persist in molecular paleopathology. We offer guidelines to mitigate the impact of these challenges, which will allow for more reliable interpretations of data in this rapidly evolving field of investigation. Expected final online publication date for the Annual Review of Microbiology Volume 73 is September 9, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.