MaxSynBio: Avenues Towards Creating Cells from the Bottom Up

Schwille, P.; Spatz, J.; Landfester, K.; Bodenschatz, E.; Herminghaus, S.; Sourjik, V.; Erb, T. J.; Bastiaens, P.; Lipowsky, R.; Hyman, A.; Dabrock, P.; Baret, J.; Vidakovic-Koch, T.; Bieling, P.; Dimova, R.; Mutschler, H.; Robinson, T.; Tang, T.; Wegner, S.; Sundmacher, K.

doi:10.1002/anie.201802288

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MaxSynBio: Avenues Towards Creating Cells from the Bottom Up

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Sourjik, V.
Microbial Networks, Department of Systems and Synthetic Microbiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Erb, T. J.
Understanding and Building Metabolism, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Schwille, P., Spatz, J., Landfester, K., Bodenschatz, E., Herminghaus, S., Sourjik, V., Erb, T. J., Bastiaens, P., Lipowsky, R., Hyman, A., Dabrock, P., Baret, J., Vidakovic-Koch, T., Bieling, P., Dimova, R., Mutschler, H., Robinson, T., Tang, T., Wegner, S., & Sundmacher, K. (2018). MaxSynBio: Avenues Towards Creating Cells from the Bottom Up. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(41), 13382-13392. doi:10.1002/anie.201802288.

引用: https://hdl.handle.net/21.11116/0000-0004-4644-1

要旨

A large German research consortium mainly within the Max Planck Society ("MaxSynBio") was formed to investigate living systems from a fundamental perspective. The research program of MaxSynBio relies solely on the bottom-up approach to synthetic biology. MaxSynBio focuses on the detailed analysis and understanding of essential processes of life through modular reconstitution in minimal synthetic systems. The ultimate goal is to construct a basic living unit entirely from non-living components. The fundamental insights gained from the activities in MaxSynBio could eventually be utilized for establishing a new generation of biotechnological processes, which would be based on synthetic cell constructs that replace the natural cells currently used in conventional biotechnology.