Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Efficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization


Lorenz,  Romy
MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)

(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available

Lorenz, R., Simmons, L. E., Monti, R. P., Arthur, J. L., Limal, S., Laakso, I., et al. (2019). Efficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization. Brain Stimulation, 12(6), 1484-1489. doi:10.1016/j.brs.2019.07.003.

Cite as: http://hdl.handle.net/21.11116/0000-0004-4744-0
Background Selecting optimal stimulation parameters from numerous possibilities is a major obstacle for assessing the efficacy of non-invasive brain stimulation. Objective We demonstrate that Bayesian optimization can rapidly search through large parameter spaces and identify subject-level stimulation parameters in real-time. Methods To validate the method, Bayesian optimization was employed using participants’ binary judgements about the intensity of phosphenes elicited through tACS. Results We demonstrate the efficiency of Bayesian optimization in identifying parameters that maximize phosphene intensity in a short timeframe (5 min for >190 possibilities). Our results replicate frequency-dependent effects across three montages and show phase-dependent effects of phosphene perception. Computational modelling explains that these phase effects result from constructive/destructive interference of the current reaching the retinas. Simulation analyses demonstrate the method's versatility for complex response functions, even when accounting for noisy observations. Conclusion Alongside subjective ratings, this method can be used to optimize tACS parameters based on behavioral and neural measures and has the potential to be used for tailoring stimulation protocols to individuals.