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Meeting Abstract

MEMRI Reveals Functional Alterations in the Auditory Midbrain of Fgf17 Knockout Mice

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Citation

Yu, X., Sudarov, A., Zaim, Y., Joyner, A., & Turnbull, D. (2007). MEMRI Reveals Functional Alterations in the Auditory Midbrain of Fgf17 Knockout Mice. In 2007 Joint Annual Meeting ISMRM-ESMRMB (pp. 99).


Cite as: http://hdl.handle.net/21.11116/0000-0004-49DB-4
Abstract
Functional alterations in the auditory midbrain were characteri zed in Fgf17 knockout mice usi ng Manganese-enhanced MRI (MEMRI). Although previous studies have shown Fgf17 to be a growth factor regulating mid-hindbrain development, only anatomical alterations of the midbrai n and cerebellum have been demonstrated in the mutant mice. Using MEMRI, we were able to analyze the reduction in the active regions as well as tonot opic reorganization in the auditory midbrain of Fgf17 mutant mice. These results enabled us to characterize the concealed functional pathology in a genetically engineered mouse models with a neurological phenotype.