Expanding the 18F-Radiochemical Space: Synthesis and Applications of 1,1-18
F-Difluorinated Alkenes

Tredwell, Matthew

doi:10.1055/s-0037-1611764

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Expanding the ¹⁸F-Radiochemical Space: Synthesis and Applications of 1,1-¹⁸F-Difluorinated Alkenes

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Tredwell, Matthew
Research Group Tredwell, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Tredwell, M. (2019). Expanding the ¹⁸F-Radiochemical Space: Synthesis and Applications of 1,1-¹⁸F-Difluorinated Alkenes. Synlett, 30(12), 1371-1376. doi:10.1055/s-0037-1611764.

Cite as: https://hdl.handle.net/21.11116/0000-0004-658F-A

Abstract

The synthesis of ¹⁸F-perfluorinated motifs from [¹⁸F]fluoride is a non-trivial undertaking as highlighted by the few methods and range of motifs that are known. In this Synpacts article we highlight our recent work on the synthesis and derivatization of 1,1-¹⁸F-difluoroalkenes to expand the accessible radiochemical space with fluorine-18.