English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Automated glycan assembly of Lewis type I and II oligosaccharide antigens

MPS-Authors
/persons/resource/persons209402

Guberman,  Mónica
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons239941

Bräutigam,  Maria
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Article.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Guberman, M., Bräutigam, M., & Seeberger, P. H. (2019). Automated glycan assembly of Lewis type I and II oligosaccharide antigens. Chemical Science, 10(21), 5634-5640. doi:10.1039/c9sc00768g.


Cite as: https://hdl.handle.net/21.11116/0000-0004-6271-E
Abstract
Human blood group related glycan antigens are fucosylated (neo-)lactoseries oligosaccharides that play
crucial roles in pathogenic processes. Lewis type-II-chain antigens mark the surface of cancer cells, but
are also mediators of bacterial infections. To investigate the biological roles of Lewis type glycans a host
of synthetic approaches has been developed. Here, we illustrate how automated glycan assembly (AGA)
using a set of six monosaccharide building blocks provides quick access to a series of more than ten
defined Lewis type-I and type-II antigens, including Lex, Ley, Lea, Leb and KH-1. Glycans with up to three
a-fucose branches were assembled following a strictly linear approach and obtained in excellent
stereoselectivity and purity.